Description And Description Of The Vaccine Formulation

4.2.1 Physical approaches As previously reviewed, penetration of substances in the skin is restricted by the SC which acts as a physical barrier, so the topical application of the vaccine formulation alone limits its transport across the skin and thus sufficient immune response is not achieved. Various physical approaches such as electroporation, iontophoresis, abrasions, tape stripping, sonophoresis, micro needles etc have been investigated to increase the penetration of substances across the skin by disrupting SC. Another approach to bypass the barrier function of SC is application of microneedles [53]. A microneedle array contains many micrometer-sized needles that can create a transport pathway large enough for proteins and NPs, but small sufficient to avoid harm [54,55]. Tape-stripping method has been shown to enhance cytotoxic T cell and cytokine immune responses upon subsequent application of various antigens and adjuvants to the skin in mice [56]. Similarly electrode preparation pads, emery paper, rub bing gauze or pumice on the skin removes cells by their abrasive effects and have been found to enhance immune responses in humans [57]. Mild hyperthermia with abrasion enhances transport of antigen into the skin, present it to LCs, migration of activated LCs to lymph nodes and trigger cascade of immune system. 4.2.2 Application of chemical enhancer in transcutenous vaccination Chemical moiety which reduces the barrier function of the stratum corneum is known asShow MoreRelatedSample Resume : Influenza Virus Vaccine918 Words   |  4 PagesName: Influenza Virus Vaccine Trade name: FLUCELVAX ®1 Product Sponsor: Novartis Vaccines and Diagnostics, Inc.1 Regulatory milestones: 1) BLA submission: November 22, 20111 2) First pre-BLA meeting: July 31, 20071 3) The original BLA submitted in February 2009 was withdrawn to include the results of the clinical endpoint study.1 4) Second pre-BLA meeting: December 15, 20101 5) BLA Approval: November 20, 2012 Pharmacologic Class: Vaccine Introduction and description of the product: FLUCELVAX ®Read MoreStrategies Management Of Pharmaceutical Company1521 Words   |  7 PagesStrategies Management of Pharmaceutical Company GSK (GLASO Smith) Strategies Formulation Introduction GlaxoSmithKline plc (GSK) is a British multinational shopper medicinal services, antibodies, biologics and pharmaceutical organization. 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Essay about The Tragic Treatment of Women in Othello

The Tragic Treatment of Women in Othello In Shakespeares drama, Othello, there are many different relationships among the main characters. The way that Shakespeare portrays these relationships sets the stage for the pain and deceit that unfolds within the play. Relations between the men of the play, Othello, Roderigo, Iago, and Cassio, undoubtedly form the main theme. Furthermore, each of the men, except Roderigo, also has woman that stands behind and cares for him. But the manor in which these women are treated is why the story ends on such a tragic note. After a careful analysis of the women, Desdemona, Emilia, and Bianca, one can see that much of the tragedy could have been avoided if only the men would have given them a chance†¦show more content†¦So, early in the play there is evidence that women are not treated equally, and thought to be incapable of making decisions that effect their own life. Desdemona is brought in by her father to the court to be questioned for her actions, she replies with utter respect to her father, but devotion to her husband To you I am bound for life and education / I am hither to your daughter. But here is my husband. And so much duty as my mother showed to you, preferring you before her father (1.3.184-190). In other words, she is grateful to her father for what he has given to her but will stand by the side of her husband. She does not hesitate to defend her husband in front of her father. This shows she has a strong inner will and is very capable of making her own decisions, a quality that Othello makes the grave mistake of ignoring. Despite the set backs in Venice, Othello and Desdemona are deeply in love and things seem to be even better when they arrive in Cyprus. Othello publicly proclaims his love for her when they meet there: Othello. It gives me wonder great as my content to see you here before me. O my souls joy, If after every tempest come such calms, may the wind blow til they have wakened death. And let the laboring bark climb hills of seas Olympus high, and duck again as low as hells from heaven! If it were now to die, Twere now to be most happy, for I fear my soul hat her content so absolute that not another comfort like to this.Show MoreRelatedTo What Extent Is Desdemona Presented as a Tragic Victim in Othello?1489 Words   |  6 PagesTo what extent is Desdemona presented as a tragic victim in the play ‘Othello’? Desdemona, the daughter of Venetian senator Brabantio, is captivated by Othello’s fables of bravery as a warrior and she falls in love with him. In view of the fact that Desdemona is a â€Å"fair† woman and Othello is â€Å"an old black ram†, commonly referred to as ‘the Moor’, their marriage indicates that her fate might be tragic. 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FromRead MoreOthello By William Shakespeare s Othello1893 Words   |  8 PagesShakespeare’s tragedy Othello deals with various issues in the tragic vein of tragedies such as Hamlet and King Lear. Marriage and associated issues stands out as a key theme and preoccupation in Othello. In Othello, various issues such as race, patriarchal attitudes and other general human frailties complicate marriages. Shakespeare portrays marriage in a very bleak light. In the beginning of the play, we see that marriage is not only a union of man and his wife but also involves various familialRead MoreWhat Way Would A Modern Audience React To The Way Race And Racism Is Portrayed In Othello?1725 Words   |  7 PagesIn the Sixteenth century, as we see clearly from Othello and other works of both Shakespeare and Cinthios original version of Othello, race was a topic of great debate and discussion. Today, in the twenty-first century the debate retains its controversy and passion. However, attitudes towards race have taken a dramatic turn during the last century. In the developed world people are now living in an increasingly cosmopolitan society would undoubtedly be more tolerant and would reject or even be offendedRead MoreLiterary Scholarship And Criticism Of Shakespeare s The Invention Of The Human 1309 Words   |  6 Pagesable to express himself more vividly and memorably than anyone else in the language† (p. 7). J.J.M. Tobin’s three components of Shakespeare’s artistry will serve as the anchors for exploring how four of Shakespeare’s prominent tragedies, Hamlet, Othello, Macbeth, and King Lear, demonstrate the faculty of Shakespeare’s expertise. 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Academic Research and Communication Skills Free Essays

The research study could not be completed without their guidance, assistance inspiration and co-operation. This project report is the fruit of intense hard work and dedication during the project work. I wish to thank our project supervisor Mr. We will write a custom essay sample on Academic Research and Communication Skills or any similar topic only for you Order Now . Fanfare Imam for his esteemed guidance during the course of project work. I am grateful to him for giving me an insight Into the realm of Academic Research and Communication Skills and build up a strong foundation. In spite of his busy schedule, he was always available whenever I required help. I appreciate all the technical help received from various sources. ABSTRACT The first and most objective of my study is the comparative analysis of consumer eying behavior from the local traditional markets and organized retail shops in India specifically Iambi. The study of consumer behavior is the most important factor for marketing of any goods and services. It suggests how an individual, groups and organization select ,buy, use and dispose the goods, services, ideas or experiences to satisfy their needs and wants. The term ‘retail’ means to put on the market, and Is a very Important aspect of every city. Without a well organized retail industry we would not have our necessities and brings us a blissful experience of shopping. Though organized retailing industry began much earlier in the developed nations, India had not actively participated. However with its vast expanse and young population, India in the 21st century emerges as a highly potential retail market. Now-a-days the phrase ‘Shopping Mall’ is synonymous to ‘comfort’ which is what each consumer today desires. How to cite Academic Research and Communication Skills, Essays

Payroll system and File Sharing for Child Protection Board

Question: Discuss about the Payroll system and File Sharing for Child Protection Board. Answer: Introduction Sydney based Child Protection board is one of the most popular social enterprises in that area. It also has branches in Brisbane and Melbourne, Australia. Their payroll system is currently managed by the staff of the organization. And, the payroll system they use is completely manual. It is currently handled over Excel files and data is exchanges with the help of Dropbox. Over the time, their payroll system have been getting burdened by newer and complex requirements which have been leading them to hire most staff to handle the increased work. There have also been huge amount of data being generated for this which is becoming difficult to handle by the team manually. To help them do their work effectively there is an urgent requirement of digital payroll solution. The Management would prefer a cloud platform over local platform to keep the cost low for the transition. Another key process File Sharing is another area for which they are looking for cloud based digital solution is File Sharing. In this report different cloud based payroll options and file sharing options would be explored apprehend cloud based systems security implications for Child Protection Board. Following analysis will assist the board take call on the Cloud based solutions for Payroll system and File sharing for Child Protection Board and its deployment for them. Cloud delivery - Deployment modules For the requirements of Child protection Board PaaS model for cloud deployment is advised as this will be easier for them to develop as well as modify it later as per their future requirements and needs. With this their file sending, application testing and development of outlines would be very streamlined. There are several other benefits also that they would have access to are cost adequacy, better security, more uptime and better software adaptability. Apart from this it is also advised that the model is deployed over private cloud that can be operated remotely. With this organisation would be able to achieve far better security system, better customization and will also get dedicated assets. (CSA, 2011). Impact on the current staff There are several other benefits that the cloud based service model would be extending to the existing staff of Child Protection Board which includes: This will enable employees to work even from outside the office. As its services would be readily accessible online. This in turn improve their productivity (Bughin, et al., 2011). Another advantage of could system is that the company data will be stored over cloud. And, thus the data will never be lost and would remain unharmed therefor, safe even in case of local computers or equipment getting damaged or in the case of local data getting lost. With digitization many manual operations that the staffs are doing currently will become automated. Thus, works will be faster and easier for the employees. Exchange of documents will be faster and easier with the help of cloud based solution. This will also felicitate integration with external centres for file sharing. Cloud vendors Payroll Services Solution Payment Model Optus Ninefold Cloud Central Cloud GB Storage based payment model $0.3 per hour at start $0.092 per hour at start Storage Allowance CPU per hour payment model $0.0175 per hour at start $0.002 per hour at start $0.025 per hour at start Data Exchange Type of Solution Xero- Operating cost MYOB- Operating cost Intuit QuickBooks- Operating cost Basic $9 per month $50 per month $12 per month Advanced /Premium $70 per month $99 per $21 per month Information security One of the key concerns for any of the data driven solutions especially over the cloud system, used by an organization is Security of their data. With the advent of cloud based system there has also been a rise in incidents of the data theft over cloud. Many bigger as well as smaller companies have fallen victim to their data falling in the hands of wrong people. Stolen data can be misused by the miscreants and at times it costs the victim organisation dearly. Therefore, it is essential that the information security levels of the cloud vendors are explored to make a choice for the desired solution. Security features of the various solution providers are listed and compared below: Cloud Based Solution Security Features Nine Fold Macquarie cloud services have recently acquired. They have locally data centers and they make sure to man and protect their systems physically. (Macquarie Telecom , 2016). Intuit QuickBooks They provide a 24 hours solution for data protection. This is achieved through a monitoring tool that is automated and which also keeps checking the servers performance for its optimum uses. There is a committed staff available round the clock especially for alarm management and video scrutiny in case of any incident of data breaches. They also provide a fully automated off-site means to store and create data backups. Apart from this, all activity of users logging in to system is assessed and recorded with the help of their in house developed ingenuous features like Audit trail and Always-On Activity Logging(Intuit QuickBooks, 2014). XERO Best feature of the services provided by Xero is that their servers are physically taken care of and are protected round the clock by 24 hour security guards, biometric systems and authorized staff. Specialists regularly audit the security of cloud and submit the reviewed and audited reports to continuously improve the system. Cloud can be accessed through a two factor rigorous authentication processes that involves password based log as well as authenticator code generated on the smartphone app of the authorized user. Apart from these, the company also delivers multi-layered security through protection systems, firewalls, intrusion detection and routers(Xero, 2016). MYOB A user Account feature developed by AccountRight is used by MYOB to implement strong password protection. Under this, their administrator has option to decide on the rights of every users according to the tasks that are to be performed apart from the files that needs to be accessed(MYOB, 2016). System also allows uses to prevent unauthorized changes made in the files by locking of important company files and documents stored its online server(MYOB, 2016). Cloud Central Cloud Central uses a secure private system for the purpose of file sharing between ports over the cloud. They provide an access which is at full root level so that the company or organization has a thorough control over the data used by all stakeholders and also over various processes that are carried over the cloud system (CloudCentral, 2016). Optus Optus offers complete end-to-end security options and solutions which can be purchased separately. It has a 6 security levels which includes detection and prevention, firewall protection, content security, intrusion, secure remote access, application control, site-to-site VPN, and anti-virus. They provide next generation firewall with provisions like address translations, stateful inspection, central administrative traffic, audit logs, anti-spoofing and high level layer filters. Apart from security assurance, they also offer a complete performance reports which comprises basic intelligences on systems uptime, memory usage, CPU usage, etc., network security reports, IPS reports, user activity reports and reports for URL filtering(Optus, 2016). Basis the evaluation of different cloud based systems, Intuit QuickBooks is suggested due to its low cost as well as its good security features for the purpose of file sharing and payroll management. For payroll services, lowest costing Ninefold was also considered but this is acquired by another firm and is probably being discontinued. The next most suitable option can be Optus which is also available at lower price. This also offers some advanced security features and options. References Bughin, J., Corb, L., Manyika, J., Nottebohm, O., Chui, M., Barbat, B. d., Said, R. (2011). The impact of Internet technologies: Search. McKinsey Company. Macquarie Telecom . (2016, September 13). Private Cloud. This ones just for you. Retrieved from Macquarie Cloud Services: https://macquariecloudservices.com/private-cloud/ CloudCentral. (2016, September 13). Cloud Servers. Retrieved from Cloud Central: https://www.cloudcentral.com.au/products/infrastructure-as-a-service/cloud-servers/ CSA. (2011). SECURITY GUIDANCE FOR CRITICAL AREAS OF FOCUS IN CLOUD COMPUTING V3.0. CSA. MYOB. (2016, September 13). Company file security. Retrieved from MYOB: https://help.myob.com/wiki/display/ar/Company+file+security Intuit QuickBooks. (2014). Security you can trust7 reasons to believe. Intuit QuickBooks. MYOB. (2016, September 13). Protecting your confidential information. Retrieved from MYOB: https://myob.com.au/myob/australia/myob-security-recommendations-1257829253909 Xero. (2016, September 13). Your data is safe with multiple layers of security. Retrieved from Xero: https://www.xero.com/accounting-software/security/ Optus. (2016). Security in the cloud. Optus.